Principal Investigator
Associate Professor
Department of Microbiology & Immunology
Bio
Education
M.D. — University of California, San Francisco
Ph.D., Biochemistry — University of California, San Francisco
Contact
Publications
Functional genomic analysis of genes important for Candida albicans fitness in diverse environmental conditions.
Xiong EH, Zhang X, Yan H, Ward HN, Lin ZY, Wong CJ, Fu C, Gingras AC, Noble SM, Robbins N, Myers CL, Cowen LE.
Cell Rep. 2024 Aug 27;43(8):114601. doi: 10.1016/j.celrep.2024.114601. Epub 2024 Aug 8. PMID: 39126650; PMCID: PMC11416860.
Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism.
Pierre JF, Peters BM, La Torre D, Sidebottom AM, Tao Y, Zhu X, Cham CM, Wang L, Kambal A, Harris KG, Silva JF, Zaborina O, Alverdy JC, Herzog H, Witchley J, Noble SM, Leone VA, Chang EB.
Science. 2023 Aug 4;381(6657):502-508. doi: 10.1126/science.abq3178. Epub 2023 Aug 3. PMID: 37535745; PMCID: PMC10876062.
Multifactor transcriptional control of alternative oxidase induction integrates diverse environmental inputs to enable fungal virulence.
Liu Z, Basso P, Hossain S, Liston SD, Robbins N, Whitesell L, Noble SM, Cowen LE.
Nat Commun. 2023 Jul 27;14(1):4528. doi: 10.1038/s41467-023-40209-w. PMID: 37500616; PMCID: PMC10374912.
Ent2 Governs Morphogenesis and Virulence in Part through Regulation of the Cdc42 Signaling Cascade in the Fungal Pathogen Candida albicans.
Lash E, Prudent V, Stogios PJ, Savchenko A, Noble SM, Robbins N, Cowen LE.
mBio. 2023 Apr25;14(2):e0343422. doi: 10.1128/mbio.03434-22. Epub 2023 Feb 21. PMID: 36809010; PMCID: PMC10128014.
Deep tissue infection by an invasive human fungal pathogen requires lipid-based suppression of the IL-17 response.
Basso P, Dang EV, Urisman A, Cowen LE, Madhani HD, Noble SM.
Cell Host Microbe. 2022 Nov 9;30(11):1589-1601.e5. doi: 10.1016/j.chom.2022.10.004. Epub 2022 Nov 1. PMID: 36323314; PMCID: PMC9744107.
Recording of DNA-binding events reveals the importance of a repurposed Candida albicans regulatory network for gut commensalism.
Witchley JN, Basso P, Brimacombe CA, Abon NV, Noble SM.
Cell Host Microbe. 2021 Jun 9;29(6):1002-1013.e9. doi: 10.1016/j.chom.2021.03.019. Epub 2021 Apr 28. PMID: 33915113; PMCID: PMC8216204.
Visualization of Candida albicans in the Murine Gastrointestinal Tract Using Fluorescent In Situ Hybridization.
Witchley JN, Penumetcha PM, Noble SM.
J Vis Exp. 2019 Nov 5;(153). doi: 10.3791/60283. PMID: 31762460.
A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans.
Brimacombe CA, Burke JE, Parsa JY, Catania S, O'Meara TR, Witchley JN, Burrack LS, Madhani HD, Noble SM.
PLoS Biol. 2019 Jun 21;17(6):e3000331.doi: 10.1371/journal.pbio.3000331. PMID: 31226107; PMCID: PMC6613695.
Candida albicans Morphogenesis Programs Control the Balance between Gut Commensalism and Invasive Infection.
Witchley JN, Penumetcha P, Abon NV, Woolford CA, Mitchell AP, Noble SM.
Cell Host Microbe. 2019 Mar 13;25(3):432-443.e6. doi: 10.1016/j.chom.2019.02.008. PMID: 30870623; PMCID: PMC6581065.
High-Throughput Screening Identifies Genes Required for Candida albicans Induction of Macrophage Pyroptosis.
O'Meara TR, Duah K, Guo CX, Maxson ME, Gaudet RG, Koselny K, Wellington M, Powers ME, MacAlpine J, O'Meara MJ, Veri AO, Grinstein S, Noble SM, Krysan D, Gray-Owen SD, Cowen LE.
mBio. 2018 Aug 21;9(4):e01581-18. doi: 10.1128/mBio.01581-18. PMID: 30131363; PMCID: PMC6106084.
Candida albicans cell-type switching and functional plasticity in the mammalian host.
Noble SM, Gianetti BA, Witchley JN.
Nat Rev Microbiol. 2017 Feb;15(2):96-108. doi: 10.1038/nrmicro.2016.157. Epub 2016 Nov 21. PMID: 27867199; PMCID: PMC5957277.
Impact of a transposon insertion in phzF2 on the specialized metabolite production and interkingdom interactions of Pseudomonas aeruginosa.
Phelan VV, Moree WJ, Aguilar J, Cornett DS, Koumoutsi A, Noble SM, Pogliano K, Guerrero CA, Dorrestein PC.
J Bacteriol. 2014 May;196(9):1683-93. doi: 10.1128/JB.01258-13. Epub 2014 Feb 14. PMID: 24532776; PMCID: PMC3993319.
Candida albicans specializations for iron homeostasis: from commensalism to virulence.
Noble SM.
Curr Opin Microbiol. 2013 Dec;16(6):708-15. doi: 10.1016/j.mib.2013.09.006. Epub 2013 Oct 10. PMID: 24121029; PMCID: PMC3855070.
Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism.
Pande K, Chen C, Noble SM.
Nat Genet. 2013 Sep;45(9):1088-91. doi: 10.1038/ng.2710. Epub 2013 Jul 28. PMID: 23892606; PMCID: PMC3758371.
Post-transcriptional regulation of the Sef1 transcription factor controls the virulence of Candida albicans in its mammalian host.
Chen C, Noble SM.
PLoS Pathog. 2012;8(11):e1002956. doi: 10.1371/journal.ppat.1002956. Epub 2012 Nov 1. PMID: 23133381; PMCID: PMC3486892.
An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis.
Chen C, Pande K, French SD, Tuch BB, Noble SM.
Cell Host Microbe. 2011 Aug 18;10(2):118-35. doi: 10.1016/j.chom.2011.07.005. PMID: 21843869; PMCID: PMC3165008.
Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity.
Noble SM, French S, Kohn LA, Chen V, Johnson AD.
Nat Genet. 2010 Jul;42(7):590-8. doi: 10.1038/ng.605. Epub 2010 Jun 13. PMID: 20543849; PMCID: PMC2893244.
Genetics and molecular biology in Candida albicans.
Hernday AD, Noble SM, Mitrovich QM, Johnson AD.
Methods Enzymol. 2010;470:737-58. doi: 10.1016/S0076-6879(10)70031-8. Epub 2010 Mar 1. PMID: 20946834.
A phenotypic profile of the Candida albicans regulatory network.
Homann OR, Dea J, Noble SM, Johnson AD.
PLoS Genet. 2009 Dec;5(12):e1000783. doi: 10.1371/journal.pgen.1000783. Epub 2009 Dec 24. PMID: 20041210; PMCID: PMC2790342.
An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth.
Elson SL, Noble SM, Solis NV, Filler SG, Johnson AD.
PLoS Genet. 2009 Sep;5(9):e1000664. doi: 10.1371/journal.pgen.1000664. Epub 2009 Sep 25. Erratum in: PLoS Genet. 2009 Oct;5(10). doi: 10.1371/annotation/17eb3a67-8f49-454b-acbf-5ff2872c27ff. PMID: 19779551; PMCID: PMC2739428.
Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans.
Liu OW, Chun CD, Chow ED, Chen C, Madhani HD, Noble SM.
Cell. 2008 Oct 3;135(1):174-88. doi: 10.1016/j.cell.2008.07.046. PMID: 18854164; PMCID: PMC2628477.
Genetics of Candida albicans, a diploid human fungal pathogen.
Noble SM, Johnson AD.
Annu Rev Genet. 2007;41:193-211. doi: 10.1146/annurev.genet.41.042007.170146. PMID: 17614788.
Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulence.
Hromatka BS, Noble SM, Johnson AD.
Mol Biol Cell. 2005 Oct;16(10):4814-26. doi: 10.1091/mbc.e05-05-0435. Epub 2005 Jul 19. PMID: 16030247; PMCID: PMC1237085.
Strains and strategies for large-scale gene deletion studies of the diploid human fungal pathogen Candida albicans.
Noble SM, Johnson AD.
Eukaryot Cell. 2005 Feb;4(2):298-309. doi: 10.1128/EC.4.2.298-309.2005. PMID: 15701792; PMCID:PMC549318.